Coarsening of the facial features

Congenital disorder of glycosylation type IIm, or early infantile epileptic encephalopathy, is an X-linked dominant severe neurologic disorder characterized by infantile-onset seizures, hypsarrhythmia, hypotonia, and severe intellectual disability with lack of speech. Conditions with this feature. Other features may also be observed, including congenital heart defects, hypoplasia of the corpus callosum, and poor overall growth with short stature and microcephaly summary by Wieczorek et al. Some individuals may experience fixation of certain joints in a permanently flexed position contractures , involuntary muscle spasms spasticity that result in slow, stiff movements of the legs and inadequate ability to sweat anhidrosis. The most severe phenotype is ISSD, characterized by severe developmental delay, coarse facial features, hepatosplenomegaly, and cardiomegaly; death usually occurs in early childhood. Except in emergency situations, PHT should not be prescribed as the first option to the treatment of female epileptic patients, because not uncommonly the cosmetic side-effects are more socially handicapping than the epileptic syndrome by itself.
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What are some of the symptoms of a pituitary condition in children?

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Progressive skeletal dysplasia dysostosis multiplex involving all bones is universal. Several conditions are associated with coarse facial features. Heads tend to be longer than normal from front to back, with a bulging forehead. FGS1 and LS share the clinical findings of cognitive impairment, hypotonia, and abnormalities of the corpus callosum. Most individuals have skeletal anomalies e.
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Coarse facial features - Wikipedia

Craniometaphyseal dysplasia, autosomal recessive type. Facial features Symptom stubs. Research in bone marrow transplant for fucosidosis and related lysosomal diseases is ongoing. FXTAS occurs in males and some females who have an FMR1 premutation and is characterized by late-onset, progressive cerebellar ataxia and intention tremor. Ferri's Clinical Advisor
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Hyperimmunoglobulin E syndrome. If the hands or feet are blue or cold from time to time, a cardiologist should check to see if the heart or the aorta might be responsible for the problem. During operation or testing, besides the increase in the amount of. That will soften up all of those strong angles and make your face look softer. Other features may also be observed, including congenital heart defects, hypoplasia of the corpus callosum, and poor overall growth with short stature and microcephaly summary by Wieczorek et al.
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